AESTHETIC MEDICINE

Advanced aesthetic treatments to help you look and feel your best.

Regenerative Medicine

Platelet Rich Plasma (PRP) to help build healthy discs, tendons, cartilage, ligaments and bones.

CONDITIONS & TREATMENTS

Treatments for excessive sweating, tendons and ligaments and pain management.

nSTRIDE ® Autologous Protein Solution (APS) Kit

This treatment is offered in our clinics of: Jonquière

The Knee OA Treatment Gap

It is well recognized that a treatment gap exists when considering solutions for osteoarthritic pain. Between conservative care and the more invasive implant solutions there are few well researched and clinically proven products that can relieve the patient’s pain and potentially delay the need for an implant.

Autologous anti-inflammatory Injection for the Treatment of Knee Osteoarthritis

The nSTRIDE APS Kit is designed to produce a novel autologous anti-inflammatory therapy to treat osteoarthritis pain in the knee via a single intra-articular injection. The nSTRIDE APS Kit is a point of care cell-concentration system designed to concentrate anti-inflammatory cytokines and anabolic growth factors to significantly decrease pain and improve knee function. nSTRIDE APS is suitable for treating patients who have Kellgren & Lawrence Stage 2 or 3 and who have failed conservative care.

Extensive Research Program and clinical results

nSTRIDE Autologous Protein Solution (APS) was developed after a multi-year research program which focused on understanding the osteoarthritic disease process in the knee and understanding the Mode of Action that an autologous blood based product could have. With the nSTRIDE Kit an Autologous Anti-Inflammatory (AAI) solution is produced from the patient’s own blood and this is injected intra articularly into the knee.

nSTRIDE APS has been shown to

• Significantly Reduces Pain Associated with Knee OA up to 2 years.
• Significantly Improves function in the Knee Joint associated with OA.
• To be effective for patients with Kellgren and Lawrence stage 2 and 3 following a single injection.
• 70% Improvement in Knee Pain at 2 years following a Single Injection.

«There is great need for a safe, effective, and cost effective treatment option for patients with moderate to severe osteoarthritis that enjoys high patient acceptance».

 

Understanding the Mode of Action of Knee Osteoarthritis

In an osteoarthritic knee, an increase in inflammatory cytokines results in cartilage degeneration and knee pain. The inflammatory proteins IL-1 and TNFα attack the cartilage. These inflammatory proteins must be stopped simultaneously to decrease pain and slow cartilage degeneration.

Understanding the Mode of Action

In pre-clinical studies, nSTRIDE APS has been shown to:
• Inhibit catabolic enzyme production from chondrocytes stimulated with IL-1ß and TNFα.
• Inhibit inflammatory cytokine production from IL-1ß-stimulated macrophages.
• Inhibit catabolic destruction of cartilage tissue.
• Protect cartilage in a meniscal-tear model.
• Reduce pain in large animals with naturally occurring OA.
• Stimulates Cartilage Cell Proliferation.

 

How does nSTRIDE APS work?

 

Autologous Anti-Inflammatory Therapy

The nSTRIDE APS Kit processes a patient’s own blood at the point-of-care to concentrate white blood cells, platelets,
and plasma proteins into a small volume of plasma. The output contains the anti-inflammatory cytokines IL-1ra, sIL-
1R, sTNF-RI, and sTNF-RII in concentrations well above what is found in native whole blood. In addition to the anti-
inflammatory cytokines, anabolic cytokines for cartilage including IGF-1 and TGF-α are also concentrated to levels well
in excess of that found in whole blood.

The APS produced by the nSTRIDE APS Kit reduces prevalent inflammatory cytokine activity which is upregulated in
osteoarthritis. These cytokines can cause both pain and cartilage degeneration. Inflammation is implicated in both
the pain and the cartilage matrix breakdown in osteoarthritic joints. The cytokines IL-1 and TNFα are the key pro-
inflammatory and catabolic targets; however, they need to be inhibited simultaneously. There are several naturally
occurring inhibitors of IL-1 and TNFα, including IL-1ra, sIL-1R, sTNF-RI, and sTNF-RII. Additionally, while decreased
activity of IL-1 and TNFα will decrease inflammation and slow the progression of cartilage degradation, anabolic
cytokines could also assist to stimulate cartilage matrix synthesis.

If your BMI is 35 or higher, you are 18 or older, and you have one or more comorbidities, you may be eligible for bariatric surgery. A comorbidity is a health problem related to obesity that is expected to get better with weight loss, such as diabetes, sleep apnea, heart disease and joint problems.

Therefore, the ideal therapy to target pain and cartilage matrix degradation caused by inflammation will include several
different anti-inflammatory cytokines and anabolic cytokines together. Autologous Protein Solution, produced using
the nSTRIDE Autologous Protein Solution Kit, contains all the anti-inflammatory proteins mentioned above, with an
added benefit of anabolic cytokines as well.

 

Clinical Results

In a series of clinical studies the autologous anti-inflammatory solution produced by the nSTRIDE APS kit has been
shown to have positive effects on knee pain and function in patients with Kellgren-Lawrence stage 2 and 3.

Further key findings were:

• Significantly Reduces Pain Associated with Knee OA up to 2 years following a single injection.
• Significant pain reduction using leukocyte–containing APS compared to baseline.
• IL-1ra concentration correlated to white blood cell content in APS.
• L-1ß concentration did not increase with white blood cell content.
• The ratio of IL-1ra to IL-1ß in APS was significantly correlated with improved WOMAC pain scores at six months post-injection.
• 72.7% of subjects were OMERACT-OARSI high responders six months post-injection.
• Significant percent improvement in pain over saline injection in double blinded pilot study.

 

Partners

 

Our clinics

Jonquière

Address:
2655 Boulevard du Royaume, local 660
Jonquière  G7S 4S9

Business hours:

Monday: 8h to 16h
Tuesday: 8h to 16h
Wednesday: 8h to 16h
Thursday: 8h to 16h
Friday: CLOSED
Saturday: CLOSED
Sunday: CLOSED

Our clinics

Jonquière

Address:
2655 Boulevard du Royaume, local 660
Jonquière  G7S 4S9

 

Business hours:

Monday: 8h to 16h
Tuesday: 8h to 16h
Wednesday: 8h to 16h
Thursday: 8h to 16h
Friday: CLOSED
Saturday: CLOSED
Sunday: CLOSED

 

Clinique de Jonquière

2655 Boulevard du Royaume
Faubourg Sagamie, local 660
Jonquière  G7S 4S9
Téléphone: 418 548-1477
Télécopieur: 418 699-1477
jonquiere@cliniquesylvainsimard.com